Biolog Phenotype MicroArray
     Serious Technology for Serious Microbiology July 2008
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Useful Links

Phenotype MicroArrays used in the study of E. coli stringent response and Salmonella fluoroquinoline resistance

Phenotype MicroArray
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  The global, ppGpp-mediated stringent response to amino acid starvation in Escherichia coli
Traxler MF, Summers SM, Nguyen HT, Zacharia VM, Hightower GA, Smith JT, Conway T. Advanced Center for Genome Technology, University of Oklahoma, Norman, OK 73019, USA. In studying the stringent response to amino-acid starvation, the authors were able to use PM technology to confirm metabolic restructuring suggested by DNA microarrays.
 
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  Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials.
Chen S, Cui S, McDermott PF, Zhao S, White DG, Paulsen I, Meng J. Department of Nutrition and Food Science, 0112 Skinner Building, University of Maryland, College Park, MD 20742, USA. PM Technology was used to show "that the AcrAB-TolC system is the predominant pump involved in the efflux of common antimicrobial agents and that TolC is required for AcrAB function in serovar Typhimurium. In addition, the data suggest that mdlAB and mdtABC (yegMNO) may contribute to intrinsic resistance in serovar Typhimurium to several less commonly tested antimicrobial compounds."
 
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Phenotype MicroArray Technology
Biolog's Phentoype MicroArray technology enables researchers to evaluate nearly 2000 phenotypes of a microbial cell in a single experiment. This integrated system of cellular assays, instrumentation and bioinformatics software provides cellular knowledge that complements molecular information, helping you interpret and find the relevant aspects in massive amounts of gene expression or proteomics data. Through comprehensive and precise quantitation of phenotypes, researchers are able to obtain an unbiased perspective of the effect on cells of genetic differences, environmental change, exposure to chemicals or drugs, and more.
 
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