Biolog Phenotype MicroArray
     Serious Technology for Serious Microbiology March 2009
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PM Technology Advances Knowledge Of Intracellular Pathogens Coxiella Burnetii And Legionella Pneumophila

Phenotype MicroArray
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  Host cell-free growth of the Q fever bacterium Coxiella burnetii
Anders Omslanda, Diane C. Cockrella, Dale Howea, Elizabeth R. Fischerb, Kimmo Virtanevac, Daniel E. Sturdevantc, Stephen F. Porcellac, and Robert A. Heinzena aCoxiella Pathogenesis Section, Laboratory of Intracellular Parasites, bElectron Microscopy Unit, and cGenomics Unit, Research Technology Section, Research Technology Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840. Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4430-4. In this breakthrough paper, the authors succeeded in culturing an "unculturable" pathogenic bacterium by utilizing Biolog Phenotype MicroArray technology. PM Technology allowed them to test the metabolic properties of non-growing cultures, which ultimately enabled them to grow the bacterium in a simple culture medium. Coxiella Burnetii causes Q Fever, a disease that can be transmitted to humans from animals. A copy of the paper can be downloaded at this link.
 
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  Legionella pneumophila couples fatty acid flux to microbial differentiation and virulence
Michele S. Swanson1,2 1Cellular and Molecular Biology Program and 2Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, USA. Mol Microbiol. 2009 Mar;71(5):1190-1204. Michele Swanson's group used Phenotype MicroArrays to identify small-chain fatty acids that trigger replicative cells to become transmissive cells. Further work showed how this signal is monitored and governs transmission trait expression. A copy of the paper can be downloaded at this link.
 
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  Biolog's Phenotype MicroArray Technology and Systems Survey
The PM team would like to thank everyone who participated in our recent survey. The number of responses exceeded our expectations and the results were very informative and supportive of our product. We will use this information for both marketing and product improvement. The survey is closed and the winner of our drawing is Diana Mader of the University of Tuebingen. Congratulations Diana!
 
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Phenotype MicroArray Technology
Biolog's Phentoype MicroArray technology enables researchers to evaluate nearly 2000 phenotypes of a microbial cell in a single experiment. This integrated system of cellular assays, instrumentation and bioinformatics software provides cellular knowledge that complements molecular information, helping you interpret and find the relevant aspects in massive amounts of gene expression or proteomics data. Through comprehensive and precise quantitation of phenotypes, researchers are able to obtain an unbiased perspective of the effect on cells of genetic differences, environmental change, exposure to chemicals or drugs, and more.
 
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