Biolog Phenotype MicroArray
     Serious Technology for Serious Microbiology January 2006
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Susan Lindquist and Coworkers at MIT Use Phenotype MicroArray Technology to Make Important New Discoveries about Peptide Metabolism in Yeast

Phenotype MicroArray
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  Harnessing Natural Diversity to Probe Metabolic Pathways
Following up on clues from PM analysis of peptide metabolism in diverse natural isolates of yeast, Oliver Homann and colleagues in Susan Lindquist's laboratory at MIT have identified previously unknown cellular activities that contribute to peptide utilization. Their observations also fit beautifully with the N-end Rules of proteolysis. The peptide containing PMs (PM6-PM8) are proving very useful in cellular analysis. Previously, Michele Swanson's laboratory at University of Michigan was able to show a role for a phagosomal transporter found in many pathogenic bacteria in the supply threonine or threonine peptides (PNAS (2005) 102:9924-9929). The complete text of this paper can be downloaded at this link http://www.pnas.org/cgi/content/full/102/28/9924. The phagosomal transporter A couples threonine acquisition to differentiation and replication of Legionella pneumophila in macrophages
 
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Phenotype MicroArray Technology
Biolog's Phentoype MicroArray technology enables researchers to evaluate nearly 2000 phenotypes of a microbial cell in a single experiment. This integrated system of cellular assays, instrumentation and bioinformatics software provides cellular knowledge that complements molecular information, helping you interpret and find the relevant aspects in massive amounts of gene expression or proteomics data. Through comprehensive and precise quantitation of phenotypes, researchers are able to obtain an unbiased perspective of the effect on cells of genetic differences, environmental change, exposure to chemicals or drugs, and more.
 
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