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Phenotype MicroArray Technology is now available for applications with nearly any mammalian cell line, including primary cells. The first four PMs (PM-M1 to PM-M4) allow the simultaneous assay of 367 carbon metabolism and energy-producing pathways in cells. These PMs are novel and powerful tools in studies related to obesity, diabetes, nutrition, aging, cancer, and toxicology. They can be used for in-depth characterization of the metabolism of cells representative of different tissues, and they can be used to assay the effects of hormones and drugs on cellular metabolic pathways. |
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Uses with mammalian cells
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- Monitor the genetic stability of cell
lines used in research.
- Identify previously undetected phenotypes
resulting from genetic changes in
cell lines.
- Detect cell variability that can
decrease reproducibility of experiments.
- Use PMs as a tool to understand gene
function.
- Conduct detailed comparisons of
cell lines with genetic differences.
- Conduct detailed comparisons of
cells with genes turned off with RNAi.
- Perform other comparisons of cell lines
in basic research and drug target studies.
- Compare normal versus abnormal or
diseased cells.
- Compare cancerous versus non-cancerous
cells.
- Compare virus infected versus virus-free
cells.
- Compare cells from various tissues.
- Compare cells in different states
or stages of development.
- Determine changes in cells with
senescence and aging.
- Determine metabolic properties of
cells.
- Determine and optimize effects of
culture conditions on cells.
- Find conditions that cause or inhibit
cell differentiation.
- Use PMs as a tool to test drug leads
- Compare phenotypic changes caused
by target gene inactivation versus
drug addition.
- Determine MOA of drugs.
- Determine secondary and side effects
of drugs.
- Test for drug synergies and antagonisms.
- Determine potential toxicology of
drug leads in multiple tissue-derived
cell lines.
- Improve Bio Processes with PMs
- QC fingerprint production strains and verify purity and stability.
- Optimize the culture medium for product yield.
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Perform cell proliferation and chemosensitivity assays
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- Two novel redox dyes available to cover all cell types.
- Many advantages over MTT and Alamar blue.
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Product Information
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For additional information please register with Biolog or contact PMServices@biolog.com. |
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All content copyright Biolog, Inc. © 2007. All trademarks and registered trademarks are the property of their respective companies. Use of this web site indicates that you accept the Terms and Conditions. Please see our User Privacy policy. If you have any questions or comments about Biolog's web site please contact us at info@biolog.com. |
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